Keshan s disease is a type of heart disease called cardiomyopathy that affects young women and children in a selenium deficient region of china. Keshan disease can lead to higher rates of cancer, cardiovascular disease and strokes. Keshan s disease is closely associated with very low dietary intakes of selenium. From 1984 to 1986, a national comprehensive scientific. Tibet currently has the highest incidence rate of kbd in china. Selenium in parenteral nutrition albert einstein college. The heart disorder that is caused by selenium deficiency is keshan disease. Read is selenium deficiency really the cause of keshan disease. Keshan disease is a potentially fatal form of cardiomyopathy disease of the heart muscle. To access free multiple choice questions on this topic, click here.
Remote work advice from the largest allremote company. As of today we have 78,789,783 ebooks for you to download for free. Request pdf keshan disease, selenium deficiency, and the. Keshan disease and kashinbeck disease are both associated with which deficiency. Keshan disease selenium for treatment of keshan disease. Essential trace elements trace elements iron, zinc and copper ultra trace elements manganese, selenium, cobalt, chromium, fluoride, iodine, and molybdenum 5 6. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free. National laboratory of biomacromolecules, institute of biophysics, chinese academy of sciences, beijing 100101, china. From 1984 to 1986, a national comprehensive scientific investigation on kd in chuxiong region of yunnan province in the southwest china was conducted. Selenium deficiency has been implicated in cardiovascular disease, infertility.
Dietary selenium deficiency combined with additional stressors are recognized to cause the. Kashin beck disease kbd is a chronic joint disease with decreased health conditions causing major functional limitations and disability of unknown origin. Keshan disease is an endemic cardiomyopathy of unknown cause in the peoples republic of china that occurs most frequently in children under 15 years. Before the chinese government supplementation program, adults in the keshan disease areas had average selenium intakes of no more than 11 mcgday. Keshan disease was first described in chinese medical literature more than 100 years ago, but not until 40 years after its widespread occurrence in 1935 was it discovered that selenium deficiency was an important factor in its aetiology 3. It was first observed in keshan province in china and since has been found elsewhere including new zealand and finland in areas where the selenium level in the soil is low. As one of several types of nutritional diseases, keshan disease is unique in that it. Keshan disease uncountable a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus. Kashinbeck disease kashinbeck disease kbd, also known as big bone disease is a disabling disease of the bones and joints that leads to stunted growth and deformity of the joints. Selenium milk that is low in fat and produced first in a nursing session is known as. Southeast siberia and north korea are other affected areas. Keshan disease is a cardiomyopathy that occurs in certain regions of china.
Infections and infectious diseases are a great burden on many societies, including the countries in the who european region. Keshan disease, selenium deficiency, and the selenoproteome. Keshan disease and mitochondrial cardiomyopathy springerlink. A heart muscle disease believed to be caused by a deficiency of the mineral called selenium in the diet.
It has also been suggested that keshan s disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which would initially present with the typical viral infection symptoms such as. For language access assistance, contact the ncats public information officer. Selenium is an essential mineral required by the body. To research the causes of keshan disease, consider researching the causes of these these diseases that may be similar, or associated with keshan disease. Keshan disease and mitochondrial cardiomyopathy request pdf. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Selenium is thought to protect against cardiovascular disease, hence, a delinquency in it causes keshan disease. If you have problems viewing pdf files, download the latest version of adobe reader.
In a typical survey, we found there was a disparity in ethnic minority of patients with kbd supplementary table s6. Distribution of soil selenium in china is potentially. Preliminary quantitative proteomics analysis in chronic and latent. Named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. A fatal heart disease first reported in keshan county of the greater metropolitan qiqihar of the heilongjiang province, mainland china, which affects children and young women.
To reduce that burden an integrated approach is required, combining health promotion, disease prevention and patient treatment. Keshan disease herbal treatment, prevention, symptoms. It was later found to be prevalent in a wide belt extending from southwest to northeast china. Kashinbeck disease kbd is a chronic, endemic type of osteochondropathy disease of the bone that is mainly distributed from northeastern to southwestern china, including 15 provinces. Kashinbeck disease expanding the spectrum of iodine. Iron most essential trace element body content 46g hb 68% ferritin % haemosiderin 12% myoglobin 3% iron enzymes 0.
Always ensure you consult your doctor before taking any type of complementary supplements. Download the 2015 std treatment tx guide app, an easytouse reference that combines information from the std treatment guidelines as well as mmwr updates, and features a streamlined interface so providers can access treatment and diagnostic information. Mega doses of any type of vitamin, mineral, amino acid or herbal supplement cannot cure illnesses and in fact can be very dangerous and produce toxic side effects and interfere with medicine you are taking. Named for keshan county in heilongjiang province, where it was rampant in 1935. Nutritional factors that may be protective against cancer include. Is selenium deficiency really the cause of keshan disease. Keshan disease kd is a lifethreatening condition that affects the heart muscle. Keshan disease, which results in an enlarged heart and poor heart function, occurs in selenium deficient children. Keshan disease is a condition that is caused to due to a low intake of selenium. Environmental risk factors such as air, water and soil pollution, chemical exposures, and climate change and ultraviolet radiation contribute to more than 100 diseases. Endemic in children aged 210 years and in women of childbearing age, this disease has a. Keshan disease is a disease of heart muscle congestive cardiomyopathy which is potentially fatal.
Kbd has a typical crescent geographical distribution, primarily in agricultural regions of eastern siberia, northern korea and in the central regions of china. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in. Three specific diseases have been associated with selenium deficiency. Several large population based intervention trials using oral administration of sodium selenite tablets showed significant reduction of keshan disease incidence. If keshan s disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. Symptoms of keshans disease health conditions vital. Kashinbeck disease kashinbeck disease fund asblvzw. Keshan disease, an endemic cardiomyopathy occurring in lowselenium areas. It mainly affects remote, rural populations and been aetiology and risk factors the aetiology of kbd remains controversial. Keshan disease and selenium status of populations in china.
It may occur due to several other factors including a virus of a lack of vitamin e. It is hard to consider keshan disease preventable because the only way to ensure that the individual is getting enough selenium would be to test the soil in the area. Keshan disease is a reversible endemic cardiomyopathy, characterized by focal myocardial necrosis associated with inflammatory infiltrates and calcification, which can lead to acute or chronic episodes of cardiogenic shock and congestive heart failure 32. Keshan disease genetic and rare diseases information. Keshan disease kd is a potentially fatal form of cardiomyopathy disease of the heart muscle endemic in certain areas of china. It is found in the soil and in marine bivalves such as oysters.
Later, it was demonstrated that the discrepancy was due to food habit, not genetic traits. Yang institute of health, chinese academy of medical sciences, beijing, peoples republic of china keshan disease is an endemic cardiomyopathy which was first observed in keshan county, heilonjiang province, northeast china. The free app is available for apple devices external icon and android devices external icon. A condition caused by deficiency of the essential mineral selenium. Studies on the relations of selenium and keshan disease. Keshan disease is an endemic cardiomyopathy which was first observed in keshan. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in the soil is low. It was first noted in the keshan province in heilongjiang, china. The prerequisite for success in this fight is the participation of all health care professionals. Ethnic korean residents in kbdendemic area were almost free of the disease. There is evidence that selenium deficiency may contribute to development of a form of heart disease, hypothyroidism, and a weakened immune system. Keshan disease is a cardiomyopathy with a dual etiology low dietary intake of. It is caused by a selenium deficiency and is characterized by pulmonary edema and heart failure. Kashinbeck disease definition of kashinbeck disease by.